WE QUOTE

" LABOKLIN Service ID: 8945

At aDermoid sinus (DS)it is atube-like invagination of the skinThe invagination extends to varying depths in the tissue structure, sometimes reaching as far as the spine, and can be felt as a cord-like structure by lifting the skin.
The dermoid sinus is filled with hair and sebum and does not cause any discomfort to the dog as long as it does not become inflamed. However, if a suddeninflammationLarge abscesses and massive infections can occur. The dermoid sinus is usually located in the midline of the spinal cord, less frequently in the cranial region.

The 10-year collaboration between Prof. Dr. Ottmar Distl (formerly TiHo Hannover), the DZRR and, since last year, LABOKLIN now enables agenetic testfor oneRisk factor for the development of a dermoid sinus (DS)in the Rhodesian Ridgeback. The genetic test was developed using genome-wide DNA sequence data and includestwo genetic markersThese markers are located on two different chromosomes, resulting in a total of nine different combinations ofMarker constellationsare possible.

Summary of details:
1.Genetic test for DS: The test analyzestwo genetic markerswhich in combination are associated with an increased risk of DS.
2.Possible genotypes: There are different combinations of genes (e.g. AACC, TTCC, ATGG, etc.).
3.Risk assessment (as of February 2025)

BSignificance for breeding

• Goal: Avoid puppies with the high-risk genotype TTCC.
• Recommendation: Matings in which TTCC could occur shouldbe avoided.
• Aids: The table shows in which matings the risk genotype TTCC cannot arise ingreen. In the matings inredsome or all of the puppies may carry the risk genotype.




Summary
Genetic testing allows for targeted breeding to minimize the risk of DS. Dogs with risky genotypes should not be bred together to further reduce the likelihood of puppies being born with DS.”




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